Bedensel i\u015flevlerimizi denetleyen ve de\u011fi\u015ftiren hormonlar\u0131n en \u00f6nemlilerinden bir b\u00f6l\u00fcm\u00fc de steroid grubuna girenlerdir. \u00d6rne\u011fin,\u00a0 kortizon, v\u00fccut s\u0131v\u0131lar\u0131n\u0131n ula\u015f\u0131m yollar\u0131ndan v\u00fccut dokular\u0131na olan y\u00f6nelmelerini y\u00f6nlendirir.\u00a0 V\u00fccuttaki kortizon miktar\u0131\u00a0 artt\u0131\u011f\u0131nda, a\u011fr\u0131 ve \u015fi\u015fkinliklerin yan\u0131 s\u0131ra iltihaplanmalar da ortaya \u00e7\u0131kar.<\/p>\n
Sentetik kortizon i\u00e7eren ila\u00e7larla yap\u0131lan tedavilerle, egzama, kolit ya da artrit gibi iltihapl\u0131 hastal\u0131klar\u0131n \u00f6n\u00fcne ge\u00e7ilebilmektedir. Sentetik steroidlerin t\u0131pta tedavi edici olarak ilk kullan\u0131m\u0131, 1939 y\u0131l\u0131nda ABD’nin Baltimore kentindeki John Hopkins Hastanesi’- nde,\u00a0 Dr. George Thorn taraf\u0131ndan ger\u00e7ekle\u015ftirildi. Bu tedavi y\u00f6nteminin en \u00f6nemli yan etkileri olarak kemik incelmesi, kan bas\u0131nc\u0131n\u0131n y\u00fckselmesi ve a\u015f\u0131r\u0131 kilo alma say\u0131labilir. Ancak yine de her y\u0131l milyonlarca insan kortizonlu ila\u00e7lar\u0131n bilin\u00e7li kullan\u0131m\u0131ndan b\u00fcy\u00fck\u00a0\u00a0 yarar g\u00f6rmektedir.<\/p>\n
Kortikosteroidler ile tedavi inflamatuvar ba\u011f\u0131rsak hastal\u0131\u011f\u0131 olan hastalar i\u00e7in de \u00f6nemli bir ilerleme sa\u011flam\u0131\u015ft\u0131r. 1950’lerde bu hastalar\u0131n ya\u015fam beklentisi olduk\u00e7a azalm\u0131\u015ft\u0131, \u00e7\u00fcnk\u00fc hastal\u0131\u011f\u0131n ciddi akut alevlenmeleri i\u00e7in hi\u00e7bir etkili tedavi bulunmamaktayd\u0131.<\/p>\n
Bu nedenle, pek \u00e7ok gen\u00e7 hasta hastal\u0131klar\u0131 nedeniyle \u00f6lmekteydiler. Kortikosteroidlerin kullan\u0131ma girmesi Crohn ve \u00fclseratif kolit hastalar\u0131n\u0131n ya\u015fam beklentilerini neredeyse normal de\u011ferlere getirmi\u015ftir. Bug\u00fcn i\u00e7in kortikosteroidlerle ana tedavi hedefi; bu ila\u00e7lar\u0131 hastalar\u0131n y\u00fcksek ya\u015fam kalitesine sahip olacaklar\u0131 \u015fekilde kullanmakt\u0131r.<\/p>\n
Bu tedavi y\u00f6nteminin en \u00f6nemli yan etkileri olarak kemik incelmesi, kan bas\u0131nc\u0131n\u0131n y\u00fckselmesi ve a\u015f\u0131r\u0131 kilo alma say\u0131labilir.<\/p>\n
Ancak yine de her y\u0131l milyonlarca insan kortizonlu ila\u00e7lar\u0131n bilin\u00e7li kullan\u0131m\u0131ndan b\u00fcy\u00fck yarar g\u00f6rmektedir.<\/p>\n","protected":false},"excerpt":{"rendered":"
Bedensel i\u015flevlerimizi denetleyen ve de\u011fi\u015ftiren hormonlar\u0131n en \u00f6nemlilerinden bir b\u00f6l\u00fcm\u00fc de steroid grubuna girenlerdir. \u00d6rne\u011fin,\u00a0 kortizon, v\u00fccut s\u0131v\u0131lar\u0131n\u0131n ula\u015f\u0131m yollar\u0131ndan v\u00fccut dokular\u0131na olan y\u00f6nelmelerini y\u00f6nlendirir.\u00a0 V\u00fccuttaki kortizon miktar\u0131\u00a0 artt\u0131\u011f\u0131nda, a\u011fr\u0131…<\/p>\n","protected":false},"author":1,"featured_media":10462,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[18],"tags":[104,105,106],"class_list":["post-125","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-saglik","tag-stereoid-tedavisi","tag-steroid","tag-tedavi"],"_links":{"self":[{"href":"https:\/\/www.ilkkimbuldu.com\/index.php?rest_route=\/wp\/v2\/posts\/125"}],"collection":[{"href":"https:\/\/www.ilkkimbuldu.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.ilkkimbuldu.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.ilkkimbuldu.com\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.ilkkimbuldu.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=125"}],"version-history":[{"count":3,"href":"https:\/\/www.ilkkimbuldu.com\/index.php?rest_route=\/wp\/v2\/posts\/125\/revisions"}],"predecessor-version":[{"id":7632,"href":"https:\/\/www.ilkkimbuldu.com\/index.php?rest_route=\/wp\/v2\/posts\/125\/revisions\/7632"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.ilkkimbuldu.com\/index.php?rest_route=\/wp\/v2\/media\/10462"}],"wp:attachment":[{"href":"https:\/\/www.ilkkimbuldu.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=125"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.ilkkimbuldu.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=125"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.ilkkimbuldu.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=125"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}