27 Temmuz 1921’de, Kanada’da Toronto \u00dcniversitesi T\u0131p Fak\u00fcltesi’nde Dr. Frederick Banting ve yard\u0131mc\u0131s\u0131 Charles Best taraf\u0131ndan elde edildi. Ayn\u0131 g\u00fcn,pankreas\u0131 al\u0131nm\u0131\u015f bir k\u00f6pe\u011fe verildi. Banting, \u015feker \u00fczerinde etkin olan hormonun pankreas taraf\u0131ndan \u00fcretildi\u011fi yarg\u0131s\u0131na varm\u0131\u015f ve bu yarg\u0131s\u0131n\u0131 kan\u0131tlamak i\u00e7in bir deney yapm\u0131\u015ft\u0131. Bu deneyde g\u00f6sterdi\u011fi ba\u015far\u0131, daha sonra milyonlarca \u015feker hastas\u0131 i\u00e7in bir sa\u011fl\u0131k kayna\u011f\u0131 oldu.<\/p>\n
\u0130ns\u00fclin ile tedavi edilen ilk ki\u015fi 14 ya\u015f\u0131ndaki \u015feker hastas\u0131 Leonard Thompsoh’a, 11 Ocak 1922 g\u00fcn\u00fc Toronto General Hospital’da,Dr.Walter \u00dc.Champbell ve Dr. Alma A. Fletcher taraf\u0131ndan ins\u00fclin tedavisi uyguland\u0131. Hastal\u0131\u011f\u0131 \u00e7ok ilerlemi\u015f bir a\u015famada oldu\u011fundan, Thompson’un, hastaneye getirildi\u011finde ya\u015fama \u015fans\u0131 \u00e7ok azd\u0131. \u0130ns\u00fclin sayesinde yeniden normal bir hayat s\u00fcrmeye ba\u015flad\u0131.<\/p>\n
1869 y\u0131l\u0131nda Berlin’de bir t\u0131p \u00f6\u011frencisi olan Paul Langerhans, mikroskopla pankreas\u0131n yap\u0131s\u0131n\u0131 incelerken, pankreas\u0131n d\u0131\u015f salg\u0131 (ekzokrin) dokusunun i\u00e7inde yay\u0131lm\u0131\u015f ve daha \u00f6nce belirlenememi\u015f h\u00fccre k\u00fcmelerine rastlam\u0131\u015ft\u0131r. Bir s\u00fcre sonra Eduard Laguesse, daha sonralar\u0131 “Langerhans adac\u0131klar\u0131” diye adland\u0131r\u0131lacak olan ve o d\u00f6nemde i\u015flevleri bilinmeyen bu h\u00fccreler i\u00e7in, sindirimde rol\u00fc olan bir salg\u0131 \u00fcretiyor olabilecekleri fikrini \u00f6ne s\u00fcrm\u00fc\u015ft\u00fcr.<\/p>\n
1889’da Polonya as\u0131ll\u0131 Alman t\u0131p doktoru Oscar Minkowski, Joseph von Mehring ile birlikte y\u00fcr\u00fctt\u00fckleri bir \u00e7al\u0131\u015fmada, pankreas\u0131n sindirim \u00fczerindeki bu \u00f6ng\u00f6r\u00fclm\u00fc\u015f rol\u00fcn\u00fc g\u00f6sterebilmek i\u00e7in sa\u011fl\u0131kl\u0131 bir k\u00f6pe\u011fin pankreas\u0131n\u0131 \u00e7\u0131karm\u0131\u015ft\u0131r. Bundan birka\u00e7 g\u00fcn sonra, Minkowski’nin hayvan bak\u0131c\u0131s\u0131 taraf\u0131ndan k\u00f6pe\u011fin idrar\u0131n\u0131n \u00fczerinde sineklerin u\u00e7u\u015ftu\u011funu farkedilmi\u015f ve k\u00f6pe\u011fin idrar\u0131 test edildi\u011finde de i\u00e7inde \u015feker oldu\u011fu ortaya \u00e7\u0131km\u0131\u015ft\u0131r. Bu, pankreas ve \u015feker hastal\u0131\u011f\u0131 aras\u0131ndaki ili\u015fkiyi ortaya koyan ilk bulgu olmu\u015ftur. 1901 y\u0131l\u0131nda ise, Eugene Opie’nin Langerhans adac\u0131klar\u0131 ile \u015feker hastal\u0131\u011f\u0131 aras\u0131ndaki ili\u015fkiyi “\u015eeker hastal\u0131\u011f\u0131n\u0131n nedeni, Langerhans adac\u0131klar\u0131ndaki harabiyettir ve yaln\u0131zca bu adac\u0131klar\u0131n k\u0131smen ya da tamamen harabolmas\u0131yla geli\u015fir<\/i>” c\u00fcmlesi ile a\u00e7\u0131k\u00e7a ortaya koymas\u0131yla, bir ba\u015fka \u00f6nemli ad\u0131m at\u0131lm\u0131\u015ft\u0131r.<\/p>\n
Ondan sonraki 20 y\u0131l boyunca, adac\u0131klar\u0131n salg\u0131lar\u0131n\u0131 toplay\u0131p, ila\u00e7 olarak kullanmak i\u00e7in bir\u00e7ok \u00e7al\u0131\u015fma yap\u0131lm\u0131\u015ft\u0131r. 1906 y\u0131l\u0131nda, George Ludwig Zuelzer k\u00f6peklerin pankreas \u00f6z\u00fct\u00fcyle iyile\u015ftirilmesinde k\u0131smen ba\u015far\u0131 sa\u011flam\u0131\u015f, fakat \u00e7al\u0131\u015fmalar\u0131n\u0131 s\u00fcrd\u00fcrememi\u015ftir.<\/p>\n
1911’le 1912 y\u0131llar\u0131 aras\u0131nda, \u015eikago \u00dcniversitesi’nden E. L. Scott suland\u0131r\u0131lm\u0131\u015f pankreas \u00f6z\u00fctlerini kullanm\u0131\u015f ve glikoz\u00fcride hafif bir azalma g\u00f6zledi\u011fini not etmi\u015ftir ama \u015fefini ikna edememi\u015f ve ara\u015ft\u0131rmas\u0131 da durdurulmu\u015ftur.<\/p>\n
1919’da ise Rockefeller \u00dcniversitesi’nden Israel Kleiner benzer etkileri g\u00f6stermi\u015ftir ama o da I. D\u00fcnya Sava\u015f\u0131 nedeni ile kesilen \u00e7al\u0131\u015fmalar\u0131na bir daha d\u00f6nememi\u015ftir.<\/p>\n
Rumen T\u0131p Okulu’nda (en) fizyoloji profes\u00f6r\u00fc olan Nicolae Paulescu, Fransa’da s\u00fcrd\u00fcr\u00fcl\u00fcp Romanya’da da patenti al\u0131nm\u0131\u015f benzer bir \u00e7al\u0131\u015fmay\u0131 1921’de yay\u0131mlam\u0131\u015ft\u0131r ve o zamandan beri de Romenler, ins\u00fclini ke\u015ffeden ki\u015fi olma unvan\u0131n\u0131n Nicolae Paulescu’ya ait oldu\u011funu savunagelmi\u015flerdir.<\/p>\n
Ancak, 1923’de Nobel \u00f6d\u00fclleri komitesi, ins\u00fclinin elde edilmesine y\u00f6nelik kullan\u0131\u015fl\u0131 bir y\u00f6ntem bulduklar\u0131 i\u00e7in Toronto \u00dcniversitesi’nden bir ekibi \u00f6d\u00fcllendirmeyi uygun bulmu\u015ftur.<\/p>\n","protected":false},"excerpt":{"rendered":"
27 Temmuz 1921’de, Kanada’da Toronto \u00dcniversitesi T\u0131p Fak\u00fcltesi’nde Dr. Frederick Banting ve yard\u0131mc\u0131s\u0131 Charles Best taraf\u0131ndan elde edildi. Ayn\u0131 g\u00fcn,pankreas\u0131 al\u0131nm\u0131\u015f bir k\u00f6pe\u011fe verildi. Banting, \u015feker \u00fczerinde etkin olan hormonun…<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[18],"tags":[420,1080],"class_list":["post-744","post","type-post","status-publish","format-standard","hentry","category-saglik","tag-insulin","tag-seker-hastaligi"],"_links":{"self":[{"href":"https:\/\/www.ilkkimbuldu.com\/index.php?rest_route=\/wp\/v2\/posts\/744"}],"collection":[{"href":"https:\/\/www.ilkkimbuldu.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.ilkkimbuldu.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.ilkkimbuldu.com\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.ilkkimbuldu.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=744"}],"version-history":[{"count":7,"href":"https:\/\/www.ilkkimbuldu.com\/index.php?rest_route=\/wp\/v2\/posts\/744\/revisions"}],"predecessor-version":[{"id":11319,"href":"https:\/\/www.ilkkimbuldu.com\/index.php?rest_route=\/wp\/v2\/posts\/744\/revisions\/11319"}],"wp:attachment":[{"href":"https:\/\/www.ilkkimbuldu.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=744"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.ilkkimbuldu.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=744"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.ilkkimbuldu.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=744"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}